AWARDS
Research & Creative Scholarship Award, University of South Florida, 1993, 1995, 2000, 2002
Teaching Incentive Program (TIP) Award, Florida State University System, 1995
Presidential Young Faculty Award, University of South Florida, 1996

PUBLICATION LIST (From USF since 1991)

From UCLA (1983-1988)
1)  Ming, L.-J.; Valentine, J. S.*  "Preparation and Characterization of Cu2Ni2 and Ag2Ni2 Superoxide Dismutase, Two New Metal-Substituted Derivatives"  J. Am. Chem. Soc. 1987, 109, 4426-4428.
2)  Ming, L.-J.; Banci, L.; Luchinat, C.; Bertini, I.; Valentine, J. S.*  "NMR Study of Cobalt(II)-Substituted Yeast and Human Copper-Zinc Superoxide Dismutase"  Inorg. Chem. 1988, 27, 728-733.
3)  Ming, L.-J.; Banci, L.; Luchinat, C.; Bertini, I.; Valentine, J. S.*  "Characterization of Copper-Nickel and Silver-Nickel Bovine Superoxide Dismutase by 1H NMR Spectroscopy"  Inorg Chem. 1988, 27, 4458-4463.
4)  Ming, L.-J.; Valentine, J. S.*  "NMR Studies of Cobalt(II)-Substituted Derivatives of Bovine Copper-Zinc Superoxide Dismutase.  Effects of pH, Phosphate, and Metal Migration"  J. Am. Chem. Soc. 1990 , 112, 4256-4264.
5)  Ming, L.-J.; Valentine, J. S.*  "NMR Studies of Nickel(II)-Substituted Derivatives of Bovine Copper-Zinc Superoxide Dismutase with Nickel(II) bound in the Copper Site"  J. Am. Chem. Soc. 1990, 112 , 6374-6383.
6)  Mota de Freitas, D.; Ming, L.-J.; Ramasamy, R.; Valentine, J. S.*  "35Cl and 1 H NMR Study of Anion Binding to Reduced Bovine Copper-Zinc Superoxide Dismutase"  Inorg. Chem. 1990, 29, 3512-3518.
 
From University of Minnesota (1988-1991)
7)  Ming, L.-J.; Que, L., Jr.;* Kriauciunas, A.; Frolik, C. A.; Chen, V. J.*  "The Coordination Chemistry of the Metal Binding Site of Isopenicillin N Synthase"  Inorg. Chem. 1990, 29, 1111-1112.
8)  Ming, L.-J.; Lauffer, R. B.; Que, L., Jr.*  "Proton Nuclear Magnetic Resonance Studies of Iron(II/III)-Amide Complexes, Spectroscopic Models for Non-Heme Iron Proteins"  Inorg. Chem. 1990, 29, 3060-3064.
9)  Jian, F.;* Peisach, J.; Ming, L.-J.; Que, L., Jr.; Chen, V. J.  "Electron Spin Echo Envelope Modulation Studies of the Cu(II)-Substituted Derivative of Isopenicillin N Synthase, a Structural and Spectroscopic Model"  Biochemistry 1991, 30, 11437-11445.
10)  Ming, L.-J.; Que, L., Jr.;* Kriauciunas, A.; Frolik, C. A.; Chen, V. J.*  "NMR Studies of Isopenicillin N Synthase, a Non-heme Iron(II) Enzyme"  Biochemistry 1991, 30, 11653-11659.
11)  Ming, L.-J.; Jang, H. G.; Que, L., Jr.*  "2D NMR Studies of Paramagnetic Diiron Complexes"  Inorg. Chem. 1992, 31, 359-364.
12)  Wang, Z., Ming, L.-J.; Que, L., Jr.;* Vincent, J. B.; Crowder, M. W.; Averill, B. A.*  "1H NMR and NOE Studies of the Purple Acid Phosphatase from Porcine Uterus and Bovine Spleen"  Biochemistry 1992, 31, 5263-5268.
13)  Elgren, T. E.; Ming, L.-J.; Que, L. Jr.*  "Spectroscopic Studies of Co(II)-Reconstituted Ribonucleotide Reductase R2 from E. coli"  Inorg. Chem. 1994, 33, 891-894.

Publications from the University of South Florida (1991-Present)
14)  Holz, R. C.; Que, L., Jr.*; Ming, L.-J.*  "NOESY Studies on the Fe(III)Co(II) Active Site of the Purple Acid Phosphatase Uteroferrin"  J. Am. Chem. Soc. 1992, 114, 4434-4436.  ( abstract 1 )

15)  Bertini, I.*; Luchinat, C.; Ming, L.-J.; Piccioli, M.; Sola, M., Valentine, J. S.  "Two-Dimensional 1 H NMR Studies of the Paramagnetic Metalloenzyme Copper-Nickel Superoxide Dismutase"  Inorg. Chem. 1992, 28, 4433-4435.  ( abstract 2 )

16)  Ming, L.-J.  "Two-Dimensional 1 H NMR Studies of Ca(II)-Binding Site in Proteins Using Paramagnetic Lanthanides(III) as Probes and Yb(III)-Substituted Bovine a-Lactalbumin as an Example"  Magn. Reson. Chem. 1993, 31, S104-S109.  (abstract 3 )

17)  Ming, L.-J.*; Lynch, J. B.; Holz, R. C.; Que, L., Jr.*  "One- and Two-Dimensional 1H NMR Studies of the Active Site of Iron(II) Superoxide Dismutase from Escherichia coli "  Inorg. Chem. 1994, 33, 83-87.  ( abstract 4 )

18)  Ming, L.-J.*; Wei, X. "An Ytterbium(III) Complex of Daunomycin, a Model Metal Complex of Anthracycline Antibiotics" Inorg. Chem. 1994, 33, 4617-4618.  ( abstract 5 )

19)  Ming, L.-J.  "Paramagnetic Lanthanide(III) Ions as NMR Probes for Biomolecular Structure and Function"  In La Mar, G. N.; Ed.  Nuclear Magnetic Resonance of Paramagnetic Molecules, NATO-ASI, Kluwer:  Dordrecht, Netherlands, 1995.  ( abstract 6 )

20)  Ming, L.-J.  "Dinuclear Metalloenzymes:  Structure, Function, and NMR Spectroscopy" Chemistry (Taiwan) 1996, 54, 69-74.  (abstract 7 )

21)  Bertolucci, C.; Ming, L.-J.*; Gonzalez, G.; Gilles-Gonzalez, M. A.* "Assignment of the Hyperfine-Shifted 1 HNMR Signals of the Heme in the Oxygen Sensor FixL from Rhizobium metiloti" Chem. Biol. 1996, 3, 561-566.  ( abstract 8 and reprint in PDF )

22)  Lehmann, T. E.; Ming, L.-J.; Rosen, M.; Que, L.* "NMR Studies of the Paramagnetic Complex Fe(II)-Bleomycin" Biochemistry 1997 , 36, 2807-2816.  (abstract 9 and reprint in PDF )

23)  Lin, L.-Y.; Park, H. I.; Ming, L.-J.* "Metal Binding and Active Site Structure of Di-Zinc Streptomyces griseus Aminopeptidase" J. Biol. Inorg. Chem. 1997, 2, 744-749.  ( abstract 10 and reprint in PDF )

24)  Wei, X; Ming, L.-J.*; Cannons, A. C.; Solomonson, L. P. " 1H and 13C NMR Studies of a Truncated Heme Domain from Chlorella vulgaris Nitrate Reductase:  Signal Assignment of the Heme Moiety" Biochim. Biophys. Acta 1998 , 1382, 129-136.  (abstract 11 and reprint in PDF )

25)  Wei, X.; Ming, L.-J.* "Comprehensive 2D 1H NMR Studies of Paramagnetic Lanthanide(III) Complexes of Anthracycline Antitumor Antibiotics" Inorg. Chem. 1998, 37, 2255-2262.  (abstract 12 and reprint in PDF )

26)  Colpas, G. J.; Brayman, T. G.; McCracken, J.; Pressler, M. A.; Babcock, G. T.; Ming, L.-J.; Colangelo, C.; Scott, R. A.; Hausinger, R. P.* "Spectroscopic Characterization of Metal Binding by Klebsiella aerogenes UreE Urease Accesory Protein" J. Biol. Inorg. Chem. 1998, 3, 150-160.  (abstract 13 and reprint in PDF )

27)  Holz, R. C.*; Bennett, B.; Chen, G.; Ming, L.-J. "Proton NMR Spectroscopy as a Probe of Dinuclear Copper(II) Active Sites in Metalloproteins.  Charaterization of the Hyperactive Copper(II)-Substituted Aminopeptidase from Aeromonas proteolytica" J. Am. Chem. Soc. 1998, 120 , 6329-6335.  (abstract 14 and reprint in PDF )

28)  Wei, X.; Ming, L.-J.* "NMR Studies of Metal Complexes and DNA Binding of the Quinone-Containing Antibiotic Streptonigrin" J. Chem. Soc. Dalton Trans. 1998, 2793-2798.  ( abstract 15 and reprint in PDF )

29)  Park, H. I.; Ming, L.-J.* "The Mechanistic Role of the Coordinated Tyr in Astacin" J. Inorg. Biochem. 1998, 72, 57-62.  (abstract 16 and reprint in PDF )

30)  Ming, L.-J. "NMR Studies of Paramagnetic Multinuclear Metalloproteins" Trends in Inorganic Chemistry 1998, 5, 205–236. ( Table of contents and Introduction, see abstract 17 )

31)  Colpas, G. J.; Brayman, T. G.; Ming, L.-J.; Hausinger, R. P.* "Identification of Metal-Binding Residues in the Klebsiella aerogenes Urease Nickel Metallochaperon, UreE" Biochemistry 1999, 38, 4078-4088. (abstract 20 and reprint in PDF )

32)  Harris, M. N.; Ming, L.-J.* "Different Phosphate Binding Modes of Streptomyces griseus Aminopeptidase between Crystal and Solution States and the Status of Zinc-Bound Water"  FEBS Lett. 1999 , 455, 321-324. (abstract 22 and reprint in PDF )

33)  Epperson, J. D.; Ming, L.-J.*; Woosley, B. D.; Baker, G. R.; Newkome, G. R.* "NMR Study of Dendrimer Using Paramagnetic Cobalt(II) as a Probe"  Inorg. Chem. 1999, 38, 4498-4502. ( introduction and abstract 19, and reprint in PDF ) (abstract of another dendrimer study )

34)  Park, H. I.; Ming, L.-J.* "A 1010 Rate Enhancement of Phosphodiester Hydrolysis by a Di-Zinc Aminopeptidase– Transition State Analogues as Substrates?" Angew. Chem. Intl. Engl. Ed. 1999, 38, 2914-2916. (abstract 21 and reprint in PDF )

35)  Ming, L.-J. "Nuclear Magnetic Resonance of Paramagnetic Metal Centers in Proteins and Synthetic Complexes" In Physical Methods in Bioinorganic Chemistry, Spectroscopy and Magnetism; Que, L., Jr., Ed.; University Science Books; February 2000.  ( Table of contents, see abstract 18 )

36)  Epperson, J. D.; Ming, L.-J.* "Proton NMR Studies of Co(II) Complexes of Bacitracin Analogous:  Insight into Structure-Activity Relationship" Biochemistry 2000, 39, 4037–4045.  abstract 23 and reprint in PDF )

37)  Ercan, A.; Park, H. I.; Ming, L.-J.* "Remarkable Enhancement of the Hydrolyses of Phosphoesters by Dimetal Centers —Streptomyces Aminopeptidase as a “Natural Model System”" Chem. Commun. 2000 , 2501–2502.  (abstract 25 and reprint in PDF )
 
38) Hasselgren, C.; Park, H. I.; Ming, L.-J.* "Metal Ion Binding and Activation of Streptomyces griseus Aminopeptidase:  Cadmium(II) Binding as a Model" J. Biol. Inorg. Chem. 2001, 6, 120–127. (abstract 24 and reprint in PDF )
 
39) Harris, M. N.; Madura, J. D.; Ming, L.-J.*; Harwood, V. J.* "Kinetic and Mechanistic Studies of Prolyl Oligopeptidase from the Hyperthermophile  Pyrococcus furiosus" J. Biol. Chem. 2001, 276 , 19310–19317. (abstract 26 and reprint in PDF )
 
40) Epperson, J. D.; Ming, L.-J.*; Baker, G. R.; Newkome, G. R.* "Paramagnetic Cobalt(II) as an NMR Probe for Dendrimer Structure, Mobility, and Coorperativity" J. Am. Chem. Soc.  2001, 123, 8583–8592. ( abstract 28 and reprint in PDF )  (introduction and abstract of another dendrimer study )

41) Epperson, J. D.; Ming, L.-J.* "Binding of Cobalt(II) and Copper(II) to Trinuclear Phospholipase C from Bacillus cereus— A Novel 1H NMR Spectrum of a “Tri-Cu(II)” Center in Protein" J. Inorg. Biochem. 2001, 87, 149-156. ( abstract 27 and reprint in PDF )

42) Park, H. I.; Ming, L.-J.* "Mechanistic Studies of the Astacin-like Serratia Metalloendopeptidase Serralysin —Highly Active (>2,000%) Co(II)- and Cu(II)-Substituted Derivatives for Further Corroboration of a 'Metallotriad' Mechanism" J. Biol. Inorg. Chem. 2002, 7, 600–610.  (abstract 29 and reprint in PDF )
 
43) Ming, L.-J.*; Epperson, J. D. "Metal Binding and Structure–Activity Relationship of the Metalloantibiotic Peptide Bacitracin" J. Inorg. Biochem. (a focused review) 2002, 91, 46–58 (abstract 30 and reprint in PDF )

44) Harris, M. N.; Bertolucci, C. M.; Ming, L.-J.* "Paramagnetic Cobalt(II) as a Probe for Kinetic and NMR Relaxation Studies of Phosphate Binding and Catalytic Mechanism of Streptomyces Dinuclear Aminopeptidase" Inorganic Chemistry 2002, 41, 5582-5588. (abstract 31 and reprint in pdf )

45) Ming, L.-J. “Structure and Function of Metalloantibiotics” Med. Res. Rev. 2003, 23, 697–762.  (abstract 32 and reprint)

46) Lykourinou-Tibbs, V.; Ercan, A.; Ming, L.-J. “Iron(III)-Chelex Resin Complex as a Prototypical Heterogeneous Catalyst for Phosphoester Hydrolysis” Catal. Commun. 2003, 4, 549–553.  (abstract 33 and reprint)

47) Hanafy, A. I.; Lykourinou-Tibbs, V.; Bisht, K. S. Ming, L.-J. “Effective Heterogeneous Hydrolysis of Phosphodiester by Pyridine-Containing Metallopolymers” Inorg. Chim. Acta. 2005, 358, 1247–1252. (abstract 34 and reprint)

48) da Silva, G. F. Z.; Tay, W. M.; Ming, L.-J. “Catechol Oxidase-Like Oxidation Chemistry of the 1–20 and 1–16 Fragments of Alzheimer’s Disease-Related β-Amyloid Peptide: Their Structure-Activity Correlation and the Fate of Hydrogen Peroxide” J. Biol. Chem. 2005, 280, 16601-16609. (abstract 35 and reprint)

49) Elder, I.; Tu, C.; Ming, L.-J.; McKenna R.; Silverman, D. N.  “Proton Transfer from Exogenous Donors in Catalysis by Human Carbonic Anhydrase II” Arch. Biochem. Biophys. 2005, 437, 106-114.  Appeared on the cover of the issue   (abstract 36, the cover, and reprint)

50) da Silva, G. F. Z.; Tay, W. M.; Ming, L.-J. “Alzheimer’s Disease-Related Copper(II)-β-Amyloid Peptide Exhibits Phenol Monooxygenase and Catechol Oxidase Activities” Angew. Chem. 2005, 44, 5501–5504.  (Accepted without alterations).  (abstract 37 and reprint)

51) da Silva, G. F. Z.; Ming, L.-J. “Catechol Oxidase Activity of Di-Cu2+-Substituted Aminopeptidase from Streptomyces griseus” J. Am. Chem. Soc. 2005, 127, 16380-16381. (abstract 38 and reprint)

52) da Silva, G. F. Z.; Reuille, R. L.; Ming, L.-J.; Livingston, B. T. “Overexpression and mechanistic characterization of blastula protease 10, a metalloprotease involved in sea urchin embyogenesis and development” J. Biol. Chem. 2006, 281, 10737–10744.  (abstract 39 and reprint)

53) Ercan, A.; Park. H. I.; Ming, L.-J. “A ‘Moonlighting’ Di-Zinc Aminopeptidase from Streptomyces griseus: Mechanisms for Peptide Hydrolysis and the 4 × 1010-Fold Acceleration of the Alternative Phosphodiester Hydrolysis” Biochemistry 2006, 45, 13779–13793.  This is our comprehensive 15-page report on the promiscuous phosphodiester hydrolytic activity of this enzyme.  (abstract 40 and reprint)

54) da Silva, G. F. Z.; Ming, L.-J. “‘Metallo-ROS’ in Alzheimer’s Disease:  Metal-Centered Oxidation of Neurotransmitters by CuII-β-Amyloid Provides an Alternative Perspective for the Neuropathology of Alzheimer’s Disease” Angew. Chem. Int. Ed., 2007, 46, 3337-3341.  (abstract and reprint)

55) Lykourinou, V.; Hanafy, A. I.; da Silva, G. F. Z.; Bisht, K. S.; Larsen, R. W.; Livingston, B. T.; Angerhofer, A.; Ming, L.-J. “How Well Should the Active Site and the Specific Recognition Be Defined for Proficient Catalyses? —Effective and Cooperative Polyphenol/Catechol Oxidation and Oxidative DNA Cleavage by a Copper(II)-Binding and H-bonding Copolymer” Eur. J. Inorg. Chem. 2008, 2584–2592.  (abstract and reprint)

56) Lin, C.-C.; Ming, L.-J.; Lee, C.-C.; Lee, S. “EPR Kinetics in Irradiated Syndiotactic Polystyrene at Elevated Temperatures” Polymer 2008, 49, 3987–3992.  (abstract and reprint)

57) Wang, S.-L.; Lin, Y.-T.; Chio, S.-H.; Liang, T.-W.; Ming, L.-J. “Purification and Characterization of Extracellular Lipases from the Newly Identified Pseudomonas monteilii TKU009 by the Use of Soybeans as the Substrate” J. Indust. Microbiol. Biotech. 2009, 36, 65–73.  (abstract and reprint)

58) da Silva, G. F. Z.; Lykourinou, V.; Angerhofer, A.; Ming L.-J. “Rectification of the Roles of Methionine-35 and Reducing Agents in Metal-Centered Oxidation Chemistry of Copper(II)-β-Amyloid with Kinetics and EPR Spectroscopy” BBA–Molecular Basis of Diseases. 2009, 1792, 49–55.  (abstract and reprint)

59) Lykourinou, V.; Hanafy, A. I.; Angerhofer, A.; Bisht, K. S.; Ming, L.-J. “Iron(III)-Polymers as Proficient Catalysts for Acid Hydrolysis of Phosphodiester and Oxidative DNA Cleavage—Insight into Rational Design of Functional Metallopolymers” Eur. J. Inorg. Chem. 2009, 1199–1207.  (abstract and reprint)

60) Ming, L.-J. “Biological Aspects of Metal Enolates” in the volume of “Metal Enolates” from The Patai’s Series of the Chemistry of Functional Groups, Zabicky, J., Ed.; Wiley: Chichester, 2009, Chapter 11, PP. 579–682.  (table of contents)

61) Tay, W. M.; Hanafy, A. I.; Angerhofer, A.; Ming, L.-J. “Metal Binding of Histatin 5 and Oxidative Activity of Its Copper Complex—A Possible Role of Salivary Copper in Antimicrobial Activity” Bioorg. Med. Chem. Lett. 2009, in press.

62) Ercan, A.; Tay, W. M.; Grossman, S. H.; Ming, L.-J. “The Role of Metal Ions in Peptide Hydrolysis and the 7 × 1010-Fold Rate Enhancement of Phosphodiester Hydrolysis by Dinuclear Streptomyces Aminopeptidase” J. Inorg. Biochem. 2009, in press.

 

Lin, Y.-S.; Ming, L.-J.; Fu, Y.-K.; Lee, S. “EPR Kinetic Studies of Radical Annihilation of γ-Ray-Irradiated 2-Hydroxyethyl Methacrylate Copolymer at Elevated Temperatures” Journal of Applied Polymer Science 2009, submitted.

Tay, W. M.; Epperson, J. D.; da Silva, G. F. Z.; Ming, L.-J. “Interactions of the Peptide Metalloantibiotic Bacitracin with Pyrophosphate and Derivatives and DNA Binding and Oxidative Cleavage”, manuscript in preparation

Tay, W. M.; da Silva, G. F. Z.; Ming L.-J. “Interaction of Flavonoids with Copper(II)-β-Amyloid —Implication toward Prevention and Treatment of Alzheimer’s Disease” in preparation

Tay, W. M.; Ming, L.-J. “Silybin Inhibition against the Oxidative Activity of Cu(II)-β-Amyloid” in prepration

Ming, L.-J. “Metallopeptides—from Drug Discovery to Catalysis” J. Chin. Chem. Soc. 2009 (an invited review) in preparation.

Ming, L.-J.; Tay, W. M. “Structure and Function of Antibiotic Metallopeptides” Current Medicinal Chemistry 2009, in prepration.

Ming L.-J.; da Silva, G. F. Z. “Inorganic Chemistry in Alzheimer’s Disease” Med. Res. Rev. 2009, in preparation.

Ming, L.-J.; Valentine, J. S. “Nickel(II) Binding to Apo Cu,Zn-Superoxide Dismutase—Binding Specificity, Migration of Metal Ions, and Implication in Mechanism” Chem. Eur. J. 2009, in preparation.

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